Table 3.
Results of Ka/Ks analysis for subsections of BACE1 and BACE2 cDNA sequences.
| Sequence | BACE1 | BACE2 | ||
|---|---|---|---|---|
| AA Coords | Ka/Ks | AA Coords | Ka/Ks | |
| (Human protein) | (Human protein) | |||
| All | 1–501 | 0.040 | 1–518 | 0.144 |
| DOMAINS | ||||
| Signal | 1–21 | 0.284 | 1–20 | 0.156 |
| Propeptide | 22–45 | 0.127 | 21–62 | 0.282 |
| Chain | 46–501 | 0.025 | 63–518 | 0.126 |
| Extracellular | 46–457 | 0.025 | 63–473 | 0.124 |
| Transmembrane | 458–478 | 0.000 | 474–494 | 0.303 |
| Intracellular | 479–501 | 0.053 | 495–518 | 0.093 |
| EXONS | ||||
| Exon 1 | 1–87 | 0.139 | 1–104 | 0.216 |
| Exon 2 | 88–117 | 0.000 | 105–134 | 0.105 |
| Exon 3 | 118–189 | 0.014 | 135–206 | 0.060 |
| Exon 4 | 190–235 | 0.032 | 207–249 | 0.057 |
| Exon 5 | 236–280 | 0.007 | 250–294 | 0.040 |
| Exon 6 | 281–314 | 0.000 | 295–328 | 0.059 |
| Exon 7 | 315–364 | 0.000 | 329–378 | 0.027 |
| Exon 8 | 365–422 | 0.008 | 379–435 | 0.211 |
| Exon 9 | 423–501 | 0.028 | 436–518 | 0.140 |
Just coding sequences were used (i.e., excluding untranslated regions). Values marked in bold exceed the overall value for the complete cDNAs.