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. Author manuscript; available in PMC: 2013 Dec 17.
Published in final edited form as: Clin Cancer Res. 2011 Sep 20;17(22):10.1158/1078-0432.CCR-11-1899. doi: 10.1158/1078-0432.CCR-11-1899

Fig. 3. Immunohistochemical evaluation of prostatectomy specimens following AdGLIPR1.

Fig. 3

Fig. 3

Results for 5 patients 1×1010 –5×1010 vp for Cohort 1,2 are shown. A Apoptotic indices (TUNEL) in tumors of patients treated with AdGLIPR1 are significantly increased compared to preoperative biopsies [Wilcoxon Signed Rank Test, p=0.0431, N=5]; B Apoptotic indices were in patients treated AdGLIPR1 (RP) was significantly higher than in retrospective (TMA) controls [Mann-Whitney Test, p=0.0295].. C. Intranuclear p27Kip1 expression in prostate cancer tissues was increased after treatment with AdGLIPR1 (RP) in 4 out of 5 patients compared to preoperative biopsies [Wilcoxon Signed Rank Test, p=0.0656]; D. Intranuclear p27Kip1 expression in patients treated AdGLIPR1 was significantly higher than in retrospective (TMA) controls [Mann-Whitney Test, p=0.0022]. Box plots were used for nonparametric data and show the median (line), interquartile range (the box includes the middle 50% of observations), and whiskers extend out to the farthest points that are not outliers. These plots allow the reader to visually compare distributions of the variables.