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. Author manuscript; available in PMC: 2013 Dec 17.
Published in final edited form as: Clin Cancer Res. 2012 Jul 3;18(18):10.1158/1078-0432.CCR-12-0912. doi: 10.1158/1078-0432.CCR-12-0912

Figure 1. Summary of ERBB2 / HER2 mutations identified in the current study (26 mutations, 25 patients).

Figure 1

(2A) Schematic organization of ERBB2 kinase domain and detailed structure of the proximal region of Exon 20. Open black arrows flank the beginning and the end of exon 20. Solid black arrows mark the specific locations of the identified mutations. Mutation hotspot is demarcated by the box. 2B. Spectrum of mutations - Detailed description of all mutations identified. Insertion sequences are demarcated by the box; Black cross marks the point mutations.