Table 1.
Demographic characteristics of subjects who received a neuropsychological battery between 1999 and 2005 according to midlife and late life alcohol consumption status
| Variable | Abstainer | Light | Moderate | Heavy | P-value |
|---|---|---|---|---|---|
| n = 59 | n = 308 | n = 156 | n = 87 | ||
| Midlife alcohol consumption status | |||||
| Agea, midlife (SD) | 43.9 (4.4) | 44.1 (4.6) | 44.6 (4.5) | 44.1 (4.5) | 0.72 |
| Agea, late life (SD) | 76.7 (4.3) | 77.1 (4.4) | 77.4 (4.4) | 76.7 (4.3) | 0.58 |
| Number of years between NP examinationsb | 6.3 (0.79) | 6.2 (1.2) | 6.1 (0.97) | 6.0 (1.0) | 0.46 |
| Midlife smoking status (%) | |||||
| Current smoker | 10 (16.9) | 98 (31.9) | 63 (40.4) | 36 (41.4) | <0.0001 |
| Former smoker | 11 (18.6) | 76 (24.8) | 46 (29.5) | 42 (48.3) | |
| Non-smoker | 38 (64.4) | 133 (43.3) | 47 (30.1) | 9 (10.3) | |
| Late life smoking status (%) | |||||
| Non-smoker | 55 (93.2) | 293 (95.4) | 150 (96.2) | 84 (96.6) | 0.78 |
| Current smoker | 4 (6.8) | 14 (4.6) | 6 (3.8) | 3 (3.4) | |
| Drinks per week (SD) | 0.0 (0.0) | 2.8 (1.4) | 10.1 (2.4) | 27.1 (12.9) | <0.0001 |
| Education (%) | |||||
| Less than high school | 5 (8.5) | 18 (5.8) | 11 (7.1) | 6 (6.9) | 0.48 |
| High school | 28 (47.5) | 126 (40.9) | 53 (34.0) | 36 (41.4) | |
| Some college | 15 (25.4) | 71 (23.1) | 41 (26.3) | 15 (17.2) | |
| College | 11 (18.6) | 93 (30.8) | 51 (32.7) | 30 (34.5) | |
| Gender (%) | |||||
| Male | 16 (27.1) | 104 (33.8) | 90 (57.7) | 70 (80.5) | <0.0001 |
| Female | 43 (72.9) | 204 (33.4) | 66 (42.3) | 17 (19.5) | |
| APOE e4 | |||||
| e4− | 53 (89.8) | 250 (81.2) | 116 (74.4) | 65 (74.7) | 0.044 |
| e4+ | 6 (10.2) | 58 (18.8) | 40 (25.6) | 22 (25.3) | |
| n = 339 | n = 115 | n = 128 | n = 28 | ||
| Late life alcohol consumption status | |||||
| Agea, midlife (SD) | 44.3 (4.6) | 44.1 (4.6) | 43.8 (4.1) | 44.6 (4.3) | 0.72 |
| Agea, late life (SD) | 77.2 (4.4) | 76.9 (4.5) | 76.7 (4.0) | 77.0 (4.2) | 0.65 |
| Number of years between NP examinationsb | 6.2 (1.1) | 6.0 (1.2) | 6.0 (1.1) | 6.0 (0.92) | 0.12 |
| Smoking, midlife (%) | |||||
| Yes | 105 (31.1) | 40 (34.8) | 48 (37.5) | 14 (50.0) | 0.0005 |
| Former | 81 (24.0) | 39 (33.9) | 45 (35.2) | 10 (35.7) | |
| No | 152 (45.0) | 36 (31.3) | 35 (27.3) | 4 (14.3) | |
| Smoking, late life (%) | |||||
| Current smoker | 17 (5.0) | 4 (3.5) | 6 (4.7) | 0 (0) | 0.78 |
| Non-smoker | 322 (95.0) | 110 (96.5) | 122 (95.3) | 28 (100.0) | |
| Drinks per week (SD) | 0.0 (0.0) | 3.1 (1.7) | 9.4 (2.8) | 22.1 (4.5) | <0.0001 |
| Education (%) | |||||
| Less than high school | 32 (9.4) | 3 (2.6) | 4 (3.1) | 1 (3.6) | <0.0001 |
| High school | 157 (46.3) | 37 (32.2) | 39 (30.5) | 10 (35.7) | |
| Some college | 78 (23.0) | 22 (19.1) | 35 (27.3) | 7 (25.0) | |
| College | 72 (21.2) | 53 (46.1) | 50 (39.1) | 10 (35.7) | |
| Gender (%) | |||||
| Male | 125 (36.9) | 60 (52.2) | 70 (54.7) | 25 (89.3) | <0.0001 |
| Female | 214 (63.1) | 55 (47.8) | 58 (45.3) | 3 (10.7) | |
| APOE e4 allele status | |||||
| e4− | 269 (79.4) | 90 (78.3) | 102 (79.7) | 23 (82.1) | 0.98 |
| e4+ | 79 (20.6) | 25 (21.7) | 26 (20.3) | 5 (17.9) | |
Bold values indicate statistical significance P < 0.05. ANOVA was used for continuous characteristics and Fisher's exact test for categorical characteristics.
aMidlife was defined as the age during the first examination. Late life was defined as the age during the eighth examination.
bBased on 494 subjects (273 abstainers, 93 light, 104 moderate and 24 heavy).