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Toxicities
| Adverse Event |
CrCl ≤ 60 mL/min (n = 14) |
CrCl > 60 mL/min (n = 18) |
|---|---|---|
| Skin Rash/HFS | ||
| Grade 1 | 3 | 6 |
| Grade 2 | 8 | 6 |
| Grade 3 | 1 | 2 |
| Grade 4 | 0 | 0 |
| Diarrhea | ||
| Grade 1 | 3 | 2 |
| Grade 2 | 5 | 4 |
| Grade 3 | 0 | 0 |
| Grade 4 | 0 | 0 |
| Fatigue | ||
| Grade 1 | 2 | 1 |
| Grade 2 | 9 | 11 |
| Grade 3 | 2 | 2 |
| Grade 4 | 0 | 0 |
| Bleeding, Number of Episodes | ||
| 0 | 13 | 16 |
| 1 | 0 | 2 |
| 2 | 1 | 0 |
| > 2 | 0 | 0 |
| Hospitalization, Number of Episodes | ||
| 0 | 11 | 14 |
| 1 | 2 | 3 |
| 2 | 0 | 0 |
| > 2 | 1 | 0 |
Abbreviations: CrCl = creatinine clearance; HFS = hand-foot syndrome
