TABLE 4.

Univariate Log Rank Survival Analysis for the Major Clinical and Pathologic Variables and for the Image Analysis Classifier QuHbIC

Variable	Overall Survival, HR (95% CI)	P †	Disease-free Survival	P	Disease-specific Survival	P
Age	1.02 (0.98-1.06)	0.47	1.02 (0.99-1.06)	0.29	1 (0.95-1.06)	0.91
Sex
Male vs. female	3.82 (0.52-28.02)	0.16	3.85 (0.53-28.22)	0.15	NA* (0-Inf)	0.18
Race
Nonwhite vs. white	0.56 (0.08-4.14)	0.57	0.48 (0.07-3.55)	0.47	1.28 (0.17-9.88)	0.81
Smoking
Ever vs. never	4.9 (1.48-16.18)	0.0039	3.98 (1.39-11.37)	0.0053	6.72 (0.88-51.43)	0.033
Treatment
Surgery and/or postoperative radiation vs. definitive	0.21 (0.1-0.44)	0.00001	0.2 (0.1-0.42)	< 0.00001	0.09 (0.03-0.27)	< 0.00001
Overall stage
III-IV vs. I-II	2.22 (0.3-16.32)	0.42	1 (0.24-4.17)	0.99	NA* (0-Inf)	0.33
Chemotherapy
Yes vs. no	2.49 (1.09-5.69)	0.026	2.08 (0.95-4.57)	0.063	2.62 (0.74-9.27)	0.12
T-stage (%)
T3-T4 vs. T1-T2	3.41 (1.64-7.08)	0.00046	2.74 (1.36-5.51)	0.0033	7.52 (2.26-25.02)	0.00011
N-stage (%)
N1-3 vs. N0	3.06 (0.41-22.61)	0.25	1.41 (0.34-5.93)	0.63	NA* (0-Inf)	0.27
N-stage
N2C or N3 vs. N0-N2B	2.62 (1.15-5.94)	0.017	2.27 (1.01-5.07)	0.040	5.55 (1.86-16.58)	0.00055
N-stage
N2B-N3 vs. N0-N2A	2.28 (1-5.17)	0.043	1.59 (0.75-3.34)	0.22	2.07 (0.62-6.88)	0.23
Resection margin status
Positive vs. negative	0.73 (0.17-3.16)	0.67	0.69 (0.16-2.97)	0.61	1.16 (0.14-9.98)	0.89
ACE Comorbidity Index
2 or 3 vs. 0 or 1	1.45 (0.59-3.57)	0.41	1.37 (0.57-3.34)	0.48	1.65 (0.45-6.01)	0.44
QuHbIC
Positive vs. negative	3.2 (1.53-6.7)	0.0011	3.64 (1.79-7.41)	0.00013	10.11 (3.36-30.38)	< 0.00001

^*Insufficient numbers in subgroups to generate a hazard ratio.

^†P-values calculated from log rank tests.

CI indicates confidence interval; HR, hazard ratio.

Values in bold are statistically significant, P < 0.05