Skip to main content
. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Biochem Pharmacol. 2013 Sep 7;86(11):10.1016/j.bcp.2013.08.063. doi: 10.1016/j.bcp.2013.08.063

Table 2.

hENT1, 2 and 4 Inhibitory Activity of Dipyridamole Analogues with opening chain analogues

graphic file with name nihms532191u2.jpg
Comp. (WL) Type R1 hENT1 IC50 (nM) hENT2 IC50 (nM) hENT4 IC50 (nM)
21 A Me2N 1,837 3,250 59566
22 B N. D. N. D. -
23 A Et2N 207.2 2,927 4121
24 B 612.5 4,223 3130
25 A (n-Propyl)2N 197 3,830 234
26 B 7,459 N. D. 97.7
27 A (n-Butyl)2N N. D. 3,310 2960
28 B N. D. 1,312 871
29 A (iso-Butyl)2N 2,627 1,962 1710
30 B 5,945 1,406 74.4
31 A (n-Pentyl)2N N. D. N. D. 45700
32 B N. D. N. D. N. D.
33 A (iso-Pentyl)2N N. D. N. D. 44200
34 B N. D. N. D. -
35 A graphic file with name nihms532191t13.jpg 538.4 2,086 103514
36 B 4,217 8,061 80352
37 A graphic file with name nihms532191t14.jpg N.D. N. D. 68400
38 B N. D. N. D. N. D.