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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Biochem Pharmacol. 2013 Sep 7;86(11):10.1016/j.bcp.2013.08.063. doi: 10.1016/j.bcp.2013.08.063

Table 3.

hENT1, 2 and 4 Inhibitory Activity of Dipyridamole Analogues with free hydrogen on the nitrogen of 4- and 8-position substituents

graphic file with name nihms532191u3.jpg
Comp. (WL) Type R1 hENT1 IC50 (nM) hENT2 IC50 (nM) hENT4 IC50 (nM)
39 A NH2 N.D. N.D. N. D.
40 A MeNH 8,461 N.D. N. D.
41 B N.D. N.D. N. D.
42 A EtNH 768.3 N.D. N. D.
43 B N.D. N.D. 38459
44 A n-PropylNH 427.7 3,500 16405
45 B 3,877 N.D. 10115
46 A iso-PropylNH 124.1 3,020 26002
47 B 5,873 N.D. 11614
48 A n-ButylNH 217 2,850 1883
49 B 1,069 2,200 3870
50 A iso-ButylNH 125.7 1,491 3055
51 B 784.2 1,490 8660
52 A tert-ButylNH 25.1 N.D. 767
53 B 6,543 N.D. 3273
54 A n-PentylNH 284.4 4,787 603
55 B N.D. N.D. 3067
56 A iso-PentylNH 142.6 1,954 495
57 B 1,173 N.D. 3760
58 A tert-PentylNH 78.9 N.D. 818
59 B 2,607 N.D. 1339
60 A graphic file with name nihms532191t15.jpg 303.8 2,708 37600
61 B N. D. N. D. N. D.
62 A graphic file with name nihms532191t16.jpg 123.3 727.2 15668
63 B 1,857 7,754 -
64 A graphic file with name nihms532191t17.jpg 20.5 1,320 12162
65 B N.D. N.D. N. D.
66 A graphic file with name nihms532191t18.jpg 85.8 N.D. 124000
67 B N.D. N.D. 65313
68 A graphic file with name nihms532191t19.jpg 1,119 N.D. N. D.
69 B N. D. N. D. N. D.
70 A graphic file with name nihms532191t20.jpg N. D. N. D. N. D.
71 B N. D. N. D. 1760