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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Biochem Pharmacol. 2013 Sep 7;86(11):10.1016/j.bcp.2013.08.063. doi: 10.1016/j.bcp.2013.08.063

Table 4.

hENT1, 2 and 4 Inhibitory Activity of Dipyridamole Analogues with modification at hydroxyl groups of dipyridamole

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Comp. (WL) R3 hENT1 IC50 (nM) hENT2 IC50 (nM) hENT4 IC50 (nM)
72 OCH2CH2OH 289.6 1,785 -
73 graphic file with name nihms532191t21.jpg 1,638 N.D. N. D.
74 N(CH2CH2OOCH)2 69.1 532 N. D.
75 N(CH2CH2OOCCH3)2 238 708 14125
76 N(CH2CH2OCH3)2 207.7 1,470 1820
77 N(CH2CH2OCH2CH3)2 767.7 N.D. 29854
78 N(CH2CH2OCH2CH2CH3)2 N.D. N.D. 139637
79 graphic file with name nihms532191t22.jpg 67.5 175 N. D.

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*

Compound 8