Table 4. Study characteristics accounting for heterogeneity of motor score—Randomised and blinded subset.

Motor Score		Effect Size % (95% CI)	Number of Animals	Number of Comparisons	Adjusted R2	p<
Pooled estimate		24.7(20.2–29.3)	1,466	79
Method used to induce SCI	Aneurysm clip	−1.7 (−44.3–40.9)	18	2	41.2%	0.0000001
	Balloon compression	19.8 (0.1–39.4)	79	6
	Compression, weight	21.9 (8–35.8)	253	8
	iridesctomy scissors	57.6 (40.2–75)	115	5
	Impactor	14.6 (7.9–21.3)	680	34
	Knife	42 (29.2–54.8)	169	11
	Unknown	23.1 (11.2–35)	152	13
Type of injury	Compression	20.2 (7.2–33.2)	350	16	25.46%	0.0007
	Contusion	14.7 (7.4–21.9)	680	34
	Hemisetion	41.1 (27.354.9)	240	12
	Transection	32.9 (21.1–44.8)	196	17
Location of injury	LowerThoracic/Lumbar	53.8 (37.9–69.7)	78	7	23.68%	0.000001
	Midthoracic	21.3 (16.4–26.2)	1,388	72
NBS	BBB	24.2 (19.1–29.3)	1,165	66	22.51%	0.0002
	Multiple tests	15.2 (2.1–28.4)	241	11
	Tarlov	84.5 (54.7–114.3)	60	2
Dose		7.08 (3.52–1.06) for each additional million cells			21.85%	0.000001
Sex	Both	53.8 (37.2–70.4)	78	7	21.28%	0.0015
	Female	21 (14.6–27.4)	813	43
	Male	22.6 (12.3–32.8)	553	28
	Unknown	3.2 (−39.2–45.6)	22	1
Allocation concealment	Concealed	37.1 (26.3–47.9)	368	20	2.21%	0.01
	Not concealed	19.4 (13.7–25.1)	1,098	59
Cell culture medium	Antibiotic+Growith Factor	23.2 (7.4–39.1)	240	13	10.84%	0.031
	Growth Factor	19.2 (12–26.3)	663	36
	Other	26 (14.4–37.7)	479	22
	Unknown	44.1 (27.7–60.6)	84	8
Cell manipulations	Differentiation	10.4 (−3.1–23.9)	33	17	10.26%	0.0224
	Diff.+Transfection	19.7 (−8.8–48.3)	33	2
	None	27.3 (19.1–35.6)	646	28
	Transfection	22.8 (8.9–36.7)	272	18
	Unknown	36 (22.4–49.6)	193	14