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. 2013 Dec 17;8(12):e81644. doi: 10.1371/journal.pone.0081644

Figure 2. Hippocampal changes after intra-amniotic LPS exposure and antenatal glucocorticoids 7 days before delivery.

Figure 2

A: The area fraction (%) of IBA1 immuno-reactivity increased significantly after intra-amniotic LPS exposure 7 days before delivery. B-D: Representative images of the IBA1 staining in the CA1 region of the hippocampus in controls (B), 7d LPS (C) and Beta-Pre + 7d LPS (D) exposed animals. E: Intra-amniotic LPS exposure significantly increased the hippocampal area fraction (%) of GFAP immuno-reactivity. F-H: Representative images of the GFAP staining in the CA1 region of the hippocampus in controls (F), 7d LPS (G) and Beta-Pre + 7d LPS (H) exposed animals. I: The area fraction (%) of synaptophysin immuno-reactivity decreased 7 days after intra-amniotic LPS exposure compared to controls. J-L: Representative images of the synaptophysin staining in the CA1 region of the hippocampus in controls (J), 7d LPS (K) and Beta-Pre + 7d LPS (L) exposed animals. Scale bar = 200 µm; scale bar insert = 25 µm. *p<0.05 versus controls and § p<0.05 between experimental groups using a one-way ANOVA with Tukey’s post hoc test.