Table 5. Top 25 genes by closeness centrality and associated GAD disease category.
|
Gene-Gene Network
|
Gene-Citation-Gene Network
|
||||
|---|---|---|---|---|---|
| Gene | Closeness | Disease Category | Gene | Closeness | Disease Category |
| MC4R | 10.22680412 | METABOLIC ( 95 ) | SH2B3 | 9.095982143 | IMMUNE ( 18 ) |
| EIF4G1 | 10.1443299 | OLIG2 | 9.095982143 | PSYCH ( 3 ) | |
| TRAF3IP1 | 9.664948454 | BLCAP | 9.080357143 | ||
| MAP1A | 9.664948454 | PSYCH ( 2 ) | BMP4 | 8.631696429 | CANCER ( 7 ) |
| PIF1 | 9.412371134 | RPGRIP1L | 8.595982143 | PSYCH ( 1 ) | |
| FEN1 | 9.412371134 | CANCER ( 5 ) | RCC1 | 8.595982143 | |
| CDKAL1 | 9.231958763 | IMMUNE ( 13 ) | RAB3IP | 8.595982143 | |
| SLC30A8 | 9.231958763 | METABOLIC ( 88 ) | RAB8A | 8.59375 | |
| IGF2BP2 | 9.231958763 | METABOLIC ( 78 ) | CEP290 | 8.59375 | |
| FTO | 9.229381443 | METABOLIC ( 197 ) | ALKBH1 | 8.495535714 | |
| NPAT | 9.146907216 | KDM5A | 8.495535714 | ||
| NDE1 | 8.677835052 | PSYCH ( 3 ) | KDM4A | 8.495535714 | CARDIOVASCULAR ( 1 ) |
| NDEL1 | 8.670103093 | KDM4C | 8.495535714 | ||
| DISC1 | 8.667525773 | PSYCH ( 38 ) | JARID2 | 8.495535714 | |
| CYBB | 8.590206186 | RPH3A | 8.457589286 | ||
| OTX1 | 8.50257732 | RPS6KB1 | 8.354910714 | CANCER ( 2 ) | |
| CHL1 | 8.425257732 | HEMATOLOGICAL ( 2 ) | NPR1 | 8.354910714 | CARDIOVASCULAR ( 12 ) |
| PSYCH ( 3 ) | |||||
| DNA2 | 8.414948454 | CHEMDEPENDENCY ( 1 ) | RICTOR | 8.354910714 | CANCER ( 1 ) |
| KCNE1 | 8.270618557 | CARDIOVASCULAR ( 37 ) | NPRL2 | 8.354910714 | |
| HHEX | 8.244845361 | METABOLIC ( 92 ) | NPR2 | 8.354910714 | CARDIOVASCULAR ( 2 ) |
| MSX2 | 8.18814433 | METABOLIC ( 5 ) | SPSB1 | 8.332589286 | |
| NEUROG1 | 8.167525773 | PSYCH ( 4 ) | SPSB2 | 8.332589286 | |
| MEF2C | 8.164948454 | METABOLIC ( 7 ) | SPSB4 | 8.332589286 | |
| MYOG | 8.164948454 | METABOLIC ( 1 ) | KDM6A | 8.207589286 | IMMUNE ( 1 ) |
| ELSPBP1 | 8.154639175 | IRS2 | 8.178571429 | METABOLIC ( 29 ) | |