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. 2013 Dec 17;8(12):e83269. doi: 10.1371/journal.pone.0083269

Figure 3. Hepatocyte-specific deletion of SH2B1 does not exacerbate HFD-induced insulin resistance and glucose intolerance.

Figure 3

(A-D) Mice were fed a normal chow diet. (A) Overnight fasting blood glucose and plasma insulin levels (18 weeks of age). f/f: n = 10; Cre: n = 9; HKO: n = 10. (B) ITT was performed on male mice at 18 weeks of age (insulin: 1 unit/kg body weight). f/f: n = 10; Cre: n = 7; HKO: n = 10. (C) GTT was performed on male mice at 19 weeks of age (D-glucose: 2 g/kg body weight). f/f: n = 10; Cre: n = 7; HKO: n = 10. (D) PTT was performed on mice at 19 weeks of age (pyruvate: 2 g/kg body weight). f/f: n = 10; Cre: n = 7; HKO: n = 10. (E-H) Mice (7 weeks of age) were fed a HFD. f/f: n = 9; Cre: n = 6; HKO: n = 8. (E) Overnight fasting blood glucose and plasma insulin (HFD for 11 weeks). (F) ITT (HFD for 11 weeks). (G) GTT (HFD for 12 weeks). D-glucose: 1 g/kg body weight. (H) PTT (HFD for 12 weeks). Data are presented as means ± SEM. P<0.05.