Table 2. Brain regions showing abnormal nodal centrality in the heroin-dependent individuals (HDIs) compared with the normal controls (NCs).
| Regions | Classification | Mean (SD) | p-value (Cohen d) | ||||
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| HDIs | NCs | HDIs | NCs | ||||
| HDIs<NCs | |||||||
| ITG.L | Association | 3.50 (1.35) | 5.23 (1.66) | 0.15 (0.02) | 0.16 (0.01) | 0.0007 (1.2) | 0.0005 (1.2) |
| MCG.L | Paralimbic | 6.62 (1.99) | 8.67 (1.99) | 0.17 (0.02) | 0.19 (0.01) | 0.002 (1.0) | 0.002 (1.0) |
| MCG.R | Paralimbic | 6.63 (1.87) | 8.08 (1.54) | 0.18 (0.02) | 0.19 (0.01) | 0.004 (0.8) | 0.006 (0.8) |
| THA.R | Subcortex | 4.03 (2.34) | 5.98 (2.18) | 0.14 (0.03) | 0.17 (0.02) | 0.045 (0.9) | 0.037 (0.9) |
| PCUN.R | Association | 5.93 (1.93) | 6.66 (1.99) | 0.17 (0.02) | 0.18 (0.02) | 0.046 (0.4) | 0.049 (0.4) |
| MFG.L | Association | 5.43 (1.32) | 6.58 (1.93) | 0.17 (0.01) | 0.18 (0.01) | — | 0.048 (0.8) |
| HDIs>NCs | |||||||
| LING.L | Association | 8.11 (1.50) | 6.19 (1.36) | 0.18 (0.01) | 0.17 (0.01) | 0.001 (1.3) | 0.005 (1.2) |
| IOG.L | Association | 6.51 (1.66) | 5.19 (1.68) | 0.17 (0.01) | 0.16 (0.01) | 0.012 (0.8) | 0.020 (0.7) |
| HIP.L | Subcortex | 4.50 (1.61) | 3.03 (1.59) | 0.15 (0.02) | 0.13 (0.03) | 0.014 (0.9) | 0.014 (0.9) |
p<0.05 (uncorrected). The symbol ‘—’ indicates no significant between-group difference. 
and 
represent the integrated nodal degree and nodal efficiency, respectively. Cohen d indicates the value of effect size. The small, medium, and large levels of the effect size are 0.2, 0.5, and 0.8, respectively, according to Cohen's definition [38]. The threshold was