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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Obesity (Silver Spring). 2013 Sep 5;22(1):110–118. doi: 10.1002/oby.20585

Table 1.

The Cardiometabolic Disease Staging System (CMDS)

The Cardiometabolic Disease Staging System (CMDS)
Stage Descriptor Criteria
Stage 0 Metabolically Healthy No risk factors
Stage 1 One or Two Risk Factors Have one or two of the following risk factors:

  1. high waist circumference (≥112 cm in men,≥88 cm in women)

  2. elevated blood pressure (systolic≥130 mmHg and/or diastolic =85 mmHg) or on anti-hypertensive medication

  3. reduced serum HDL cholesterol (<1.0 mmol/L or 40 mg/dL in men; <1.3 mmol/L or 50 mg/dL in women) or on medication

  4. elevated fasting serum triglycerides (≥1.7 mmol/L or 150 mg/dL) or on medication
Stage 2 Metabolic Syndrome or Prediabetes Have only one of the following three conditions in isolation

  1. Metabolic Syndrome based on three or more of four risk factors: high waist circumference, elevated blood pressure, reduced HDL-c, and elevated triglycerides

  2. Impaired Fasting Glucose (IFG; fasting glucose ≥5.6 mmol/L or100 mg/dL)

  3. Impaired Glucose Tolerance (IGT; 2-hour glucose ≥7.8 mmol/L or140 mg/dL)
Stage 3 Metabolic Syndrome+ Prediabetes Have any two of the following three conditions:

  1. Metabolic Syndrome

  2. IFG

  3. IGT
Stage 4 T2DM and/or CVD Have Type 2 Diabetes Mellitus (T2DM) and/or Cardiovascular Disease (CVD):

  1. T2DM (fasting glucose ≥126 mg/dL or 2-hour glucose ≥200 mg/dL or on anti-diabetic therapy)

  2. active CVD (angina pectoris, or status post a CVD event such as acute coronary artery syndrome, stent placement, coronary artery bypass, thrombotic stroke, non-traumatic amputation due to peripheral vascular disease)