Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Dec 17;8(12):e85087. doi: 10.1371/journal.pone.0085087

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 McCarroll, Nechiporuk

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Before 12 hpf, Fgf3 and Fgf8 specify cells of the posterior placodal area that will give rise to the otic and EB placodes. Shortly after, between 14 and 22 hpf, Fgf10a, expressed by the anterior lateral line precursors and the forming otic vesicle, and Fgf3, expressed by the endoderm, are required for EB placode development by promoting the expression of Pax2a and Sox3 in a subset of cells of the Foxi1+ placodal competent ectoderm. By 24 hpf, EB placodes are fully developed. Abbreviations: NT, neural tube; MHB, midbrain hindbrain boundry; f, facial placode; ov, otic vesicle; All, anterior lateral line; g+v, glossopharyngeal/vagal placode.