Figure 2. Post-natal editing levels in filamin in wild-type (A) and ADAR2-knockout animals (B). (A) In the wild-type, post-natal editing levels in filamin A increase from P0 to P120. Editing levels are highest in the gastrointestinal tract, reaching more than 90% in the stomach. Editing in neuronal tissue is comparatively modest, reaching almost 40% in the cerebellum. (B) In ADAR2^−/− animals, editing rates are strongly reduced and decrease from P0 to P120 in spleen pancreas and liver while editing increases in the nervous system. Highest editing levels are reached in spleen, pancreas, liver, and bone, reaching at least 25% in the spleen.