Predicted and observed responses of macroinvertebrates to OA. Predictions are based on the generalized main conclusions of meta-analyses and reviews of physiological laboratory experiments [5,6,33]. Observed in situ responses are from the CO2 seeps in PNG (this study), and the Mediterranean at a pH of more than 7.7 [8,10,11]. Thick arrows represent widespread responses from many taxa; thin arrows represent data from fewer taxa; direction of arrows represents increase (⇑, ↑), little difference (⇔, ↔) or decline/greater reduction (⇓, ↓).