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. 2013 Oct 23;33(43):16897–16914. doi: 10.1523/JNEUROSCI.1871-13.2013

Figure 3.

Figure 3.

8-Br-cGMP mediates a partial rescue of cell migration of MGE and CGE cells from Dlx1/2−/− mutants assessed using Matrigel explants and Boyden chamber assays. A–D′, Matrigel explant cell migration assays of E13.5 MGE and CGE comparing WT (A–D) and Dlx1/2−/− mutants (A′–D′) treated with DMSO (A, A′, C, C′) or 8-Br-cGMP (B, B′, D, D′). E, F, Histograms reporting the percentage change in the MGE (E) and CGE (F) explant outgrowth (normalized to DMSO). Data are the mean ± SEM. *p ≤ 0.05 (paired Student's t test). **p ≤ 0.01 (paired Student's t test). Scale bars: A–D′, 500 μm. A, A′, p = 0.02241; B, B′, p = 0.00884; A′, B′, p = 0.00246. G, Boyden chamber assay showing that 8-Br-cGMP partially rescues the Dlx1/2−/− mutant (p = 0.02645). *p ≤ 0.05. **p ≤ 0.01.