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. 2013 Dec 5;12:175. doi: 10.1186/1475-2840-12-175

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Copyright © 2013 Eskens et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Vascular clearance and urine appearance of dextrans. A. Left. Calculated amount of 70 (Dex70) and 40 kDa dextran (Dex40) cleared from the circulation after injection (t = 0 min) until the last time point of blood sampling (t = 30 min). Right: cleared amount of Dex70 divided by Dex40. *, P < 0.05 versus C57Bl/6 mice; #, P < 0.05 metformin versus control db/db. B. Left. Measured amount of dextran in urine collected during the experiment and in bladder after euthanization of the animal (t = 35 min). Right: urine amount of Dex70 divided by Dex40. *, P < 0.05 versus C57Bl/6 mice.

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