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. 2014 Jan 1;34(1):10–21. doi: 10.1523/JNEUROSCI.4761-12.2014

Figure 4.

Figure 4.

Increasing O-GlcNAcylation induces long-term synaptic depression at CA3–CA1 synapses. A, B, Glucosamine application (GlcN, 10 min) at (A) 5 mm (n = 11) or (B) 100 μm (n = 6) induces synaptic depression in extracellular dendritic field potential recordings at CA3–CA1 synapses in acutely to prepared hippocampal slices. C, D, Pharmacological blockade of O-GlcNAcase (10 min) using (C) PUGNAc (30 μm, n = 9) or (D) TMG (1 μm, n = 6) induces synaptic depression. E, Repeated GlcN 5 mm application saturates the synaptic depression (n = 4). *p < 0.05, **p < 0.001, and ***p < 0.0001. Error bars indicate SEM. Calibration: 0.4 mV, 10 ms.