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. 2014 Jan 1;34(1):313–326. doi: 10.1523/JNEUROSCI.2425-13.2014

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Copyright © 2014 the authors 0270-6474/14/340313-14$15.00/0

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Figure 10. — Knockdown of NEAT1 and MALAT1 blocks the hADSC- and CM-mediated reduction in hippocampal cell loss in young rats exposed to TBI. Administration of CM kdNEAT1 and CM kdMALAT1 significantly blocked the therapeutic effects relative to CM, CM kdscramble, and sham control (one-way ANOVA, F_(5,31) = 23.24, p < 0.001). Graph shows the percentage loss of CA3 hippocampal neurons. There is no therapeutic effects to reduce the TBI-associated neuronal cell loss in young rats treated with CM kdNEAT1 or CM kdMALAT1 compared with vehicle, CM, CM kdscramble, or sham control (p > 0.05). *, Significantly different from sham control; &, significantly different from TBI–CM; #, significantly different from TBI–CM kdscramble using Bonferroni's test.