Table 1.
Effect of CGRP (1 μm) on the electroresponsive properties of BNST-AL neuronsa
| Control | CGRP | p | n | |
|---|---|---|---|---|
| Resting potential (mV) | −61.5 ± 1.5 | −60.9 ± 1.4 | 0.27 | 26 |
| Input resistance (mΩ) | 715.7 ± 74.1 | 731.2 ± 74.6 | 0.38 | 26 |
| Time constant (ms) | 46.9 ± 4.6 | 50.6 ± 4.0 | 0.25 | 26 |
| Rheobase (pA) | 40.8 ± 6.1 | 42.5 ± 5.7 | 0.44 | 12 |
| Spike threshold (mV) | −48.1 ± 2.2 | −49.4 ± 2.3 | 0.31 | 12 |
| Spike latency (ms) | 98.2 ± 13.3 | 104.3 ± 15.9 | 0.7 | 12 |
| Spike amplitude (mV) | 87.8 ± 3 | 83.6 ± 3.63 | 0.16 | 12 |
| Spike duration at half amplitude (ms) | 0.48 ± 0.03 | 0.49 ± 0.01 | 0.8 | 12 |
| Firing rate at rheobase (Hz) | 0.75 ± 0.21 | 0.75 ± 0.14 | 1 | 12 |
aValues are mean ± SEM. We restricted our analysis of passive properties and spike characteristics to cells tested in the same conditions (before and after CGRP), with no other drugs present. Also, 8 additional cells tested with 250 nm CGRP were not included because this dose had no effect. Finally, for the spike characteristics, in 14 of the 26 cells meeting our selection criteria, no responses to positive current pulses were recorded.