Table 2.
Biological functions and roles in breast cancer of proteins differentially expressed in CD133 low and CD133 high cells
| Proteins | Main function/Biological process | Known roles in breast cancer | CD133 high versus CD133 low |
|---|---|---|---|
| Tm4 |
Actin-binding protein/Cell motility |
Metastasis (32), Chemotherapy resistance (34) |
Up |
| 14-3-3 ϵ |
Protein binding/Cell cycle |
Chemotherapy resistance (34) |
Down |
| 14-3-3 σ |
Protein binding/Cell cycle, apoptosis |
Tumor suppression (35) |
Down |
| 14-3-3 β/α |
Protein binding/Cell cycle, apoptosis |
Chemotherapy resistance (34) |
Down |
| TCP-1-α |
Molecular chaperone/Cell motility |
Metastasis (36) |
Down |
| LEI |
Protease inhibitor/Protein metabolism |
Cell migration and invasiveness suppression (37) |
Down |
| AdoHcyase |
Hydrolase/Protein metabolism |
Oncogenic (38) |
Up |
| eIF-2A |
Initiation factor/Protein metabolism |
Protein biosynthesis (39) |
Down |
| PP2A- β |
Protein phosphatase/Apoptosis |
Tumor suppression (40) |
Down |
| eIF3β |
Initiation factor/Protein metabolism |
Oncogenic (41) |
Up |
| DDAH-1 |
Hydrolase/Metabolic pathways |
Unknown |
Down |
| PPase |
Pyrophosphate hydrolysis/Metabolic pathways |
Chemotherapy resistance (34) |
Down |
| Annexin A3 |
Phospholipase A2 inhibitor/Metabolic pathways |
Chemotherapy resistance (34) |
Down |
| CapZ β |
Actin capping/Cell motility |
Chemotherapy resistance (34) |
Down |
| PA28γ | Protein binding/Cell cycle, apoptosis | Unknown | Down |