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. 1986 Sep;83(18):7064–7068. doi: 10.1073/pnas.83.18.7064

Selective ablation of atheromas using a flashlamp-excited dye laser at 465 nm.

M R Prince, T F Deutsch, A H Shapiro, R J Margolis, A R Oseroff, J T Fallon, J A Parrish, R R Anderson
PMCID: PMC386653  PMID: 3462744

Abstract

Ablation of human atheromas with laser pulses that had only a small effect on normal artery tissue was shown in vitro in air and under saline using 1-mu sec pulses at 465 nm from a flashlamp-excited dye laser. At this wavelength, there is preferential absorption in atheromas due to carotenoids. The threshold fluence for ablation was 6.8 +/- 2.0 J/cm2 for atheromas and 15.9 +/- 2.2 J/cm2 for normal aorta tissue. At a fluence of 18 J/cm2 per pulse, the ablated mass per unit of energy ranged from 161 to 370 micrograms/J for atheromas and from 50 to 74 micrograms/J for normal aorta tissue. Ablation products consisted of cholesterol crystals, shredded collagen fibers, and small bits of calcific material. Most debris was less than 100 micron in diameter, but a few pieces were as large as 300 micron. High-speed photography of ablation in air suggested explosive ejection of debris, caused by vapor formation, at speeds on the scale of 300 m/sec. Histological analysis showed minimal thermal damage to residual tissue. These data indicate that selective laser ablation of atheromas is possible in vitro.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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