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. 2013 Dec 18;5:10. doi: 10.3389/fnene.2013.00010

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Copyright © 2013 Pandya, Nukala and Sullivan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Calcium decreases mitochondrial bioenergetics in a dose-dependent manner. Increasing doses of calcium were added to the mitochondria after the addition of the complex I substrates pyruvate and malate. An increase in the nmol of oxygen consumed upon addition of calcium was observed, which reaches significance at 500 nmol/mg mitochondrial protein and later. Similarly, with increasing calcium concentrations, a trend in decreased bioenergetic response was observed in State III (ADP) and State V (FCCP) respiration whereas State IV(oligomycin) response remained unaltered. Calcium did not affect the complex II (Succinate) driven oxygen consumption. Data represent group means ± s.e.m.; n = 3 per group. One-Way ANOVA followed by Fisher's post-hoc test; ^*p < 0.05 compared to 0 nmol/mg calcium.