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. 2013 Nov 21;13:555. doi: 10.1186/1471-2407-13-555

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Copyright © 2013 Kimura et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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3-MPA-treated cells suppress translocation of β-catenin to the nucleus and MMP7 activation. a Immunoblotting analysis of β-catenin in the nuclei of 3-MPA-treated cells. β-catenin expression in the nucleus of 3-MPA-treated cells is decreased markedly compared with that in control cells. β-catenin expression in the cytoplasm does not differ significantly between 3-MPA-treated cells and control cells. b Quantification of MMP7 mRNA level in 3-MPA-treated cells by qRT-PCR analysis. MMP7 mRNA is significantly down-regulated in 3-MPA-treated cells compared with control cells. c Casein zymography analysis of MMP7 activity in 3-MPA-treated cells. Cell culture media are collected and concentrated, MMP7 activity is analyzed by casein zymography. MMP7 secretion is decreased significantly in 3-MPA-treated cells compared with control cells.