Table 1.
Hypothetical HS-interacting proteins.
| Cellular location | Total | Protein |
|---|---|---|
| Intracellular | 154 | Nlrp3, Nkap, Lrp5, Lyst, Lck, Irak4, Sla2, Mx2, Syk, Oasl2, Tcf3, Myo1e, Atp7a, Cplx2, Tusc2, Ak7, Vav3, Blnk, Spta1, Skap1, Fgr, Pmaip1, Aim2, Shb, Ddx60, Dapk3, Nfkb2, Apobec3, Ripk2, Nod1, Sptb, Oas1d, Mapk14, Ptbp3, March8, Dapk1, Zfp385a, Bcl2, Mecom, Chd7, Gpam, Ap3d1, Lcp2, Arid4a, Polr3a, Tnfaip1, Kat6a, Ung, Myo9b, Bcl6, Eprs, Sp3, Bag6, Plcg1, Nbn, Pml, Klf1, Rb1, Sfxn1, Bcl11a, Farp2, Jarid2, Xrcc6, Itk, Myo1f, Nlrc5, Cyp27b1, Ikzf1, Ddx58, Pip4k2a, Ciita, Foxj1, Rnf168, Prkdc, Pms2, Mll1, Stk3, Mef2c, Ahctf1, Prkx, Rag1, Batf3, Map3k14, Ilf2, Herc6, Card11, Card9, Dlg1, Itch, Dyrk3, Tnip3, Cdk6, Irgm1, Rnf31, Apc, Unc13d, Tlr13, Tlr8, Nedd4, Msh6, Pcid2, Sh2b2, Aicda, Myh9, Pik3cd, Zap70, Vav1, Stat5a, Tgtp1, Mx1, Enpp2, Dock2, Pgm3, Unc93b1, Plcg2, Stxbp2, Ifi44l, Zfp35, Inpp5d, Oas3, Cblb, Ostm1, Bcl11b, Eps8, Prkd1, Ctnnbl1, Polr3b, Samhd1, Nlrc4, Tec, Tet2, Map3k5, Pou1f1, Ncaph2, Stat6, Smarca4, Fnip1, Jak3, Cactin, Dicer1, Atm, Ikbkg, Satb1, Eif2ak2, Stap1, Msh3, Sgpl1, Cdk13, Foxe1, Zc3h8, Spib, Maea, March1, Ank1, Mink1 |
| Plasma membrane | 42 | Mpzl2, Adam10, Ntrk1, Icosl, Cxcr5, Cd97, Tlr6, Pde2a, Adam9, Tlr1, Ccr3, Treml2, Tril, Tek, Lrrc8a, Il2ra, Selp, Fas, Hfe, Cd83, Cd22, Ccbp2, Ctla4, Tlr2, Klre1, Gpr183, Ccr7, Abcc9, Hoxb4, H2-M5, Thsd1, Dcstamp, Il7r, Procr, Amica1, Chrnb2, Tnfrsf13c, Csf1r, Tlr4, Tyr, Cd93, Eda, Cd40lg |
| Extracellular | 24 | Masp1, Ccl25, Osm, Il9, Bmp4, Inhba, Pdgfb, Scg2, Hc, Fam20c, Wnt2b, Lrrc17, Gas6, C7, Il1a, Wnt5a, Cxcl12, AI182371, C4b, Cxcl5, C8b, Ccl17, Serping1, Ccl28 |
| Intracellular, plasma membrane, and extracellular | 1 | Hpse |
| Intracellular and plasma membrane | 3 | Blk, Flt1, Flt3 |
| Intracellular and extracellular | 2 | Isg15, Prg4 |
| Plasma membrane and extracellular | 8 | Tgfb1, Vegfa, Enpp3, Ctsg, C8a, Ptpro, Adam17, Enpp1 |
List of murine proteins that carry “consensus” heparin/HS-binding motifs. The motifs adapted for bioinformatic screens are the standard motifs, which are primarily XBBBXXBX or XBBXBX (17) (http://gduserv.anu.edu.au/~cameron/protein.html). Short motifs are truncated versions of the standard motifs XBBBBX, BBXBB, or BBXXXBB (B = basic amino acids R, K, H; X = A, V, I, L, M, F, Y, W). Only proteins in the UniProt database (www.uniprot.org) that are known to play immunological roles are listed.