Table 4.
Seroconversion rates for Plasmodium falciparum merozoite antigens using age specific sero-prevalence
|
Site |
Lampung
#
|
Purowejo |
||
|---|---|---|---|---|
| Transmission season (N) | Low Lambda (95% CI) | High (490) | Low (488) | High (531) |
|
aPfMSP1-19 |
|
|
|
|
| Current |
0.004 (0.001-0.01) |
0.013 (0.007-0.02) |
0.006 (0.004-0.008) |
0.011 (0.009-0.014) |
| Previous |
0.067 (0.05-0.087) |
0.091 (0.07-0.12) |
|
|
|
bPfAMA1 |
|
|
|
|
| Current |
0.007 (0.003-0.014) |
0.019 (0.011-0.031) |
0.009 (0.007-0.012) |
0.013 (0.01-0.016) |
| Previous |
0.096 (0.072-0.12) |
0.078 (0.056-0.11) |
|
|
|
bCombined |
|
|
|
|
| Current |
0.035 (0.026-0.049) |
0.053 (0.039-0.073) |
0.019 (0.015-0.022) |
0.032 (0.03-0.038) |
| Previous | 0.124 (0.084-0.18) | 0.091 (0.058-0.14) | ||
#for Lampung a model with two separate forces of infection (with a change point 10 years before present) fitted the data better than a model with a single force of infection.
afor PfMSP1-19 the rate of reversion in the seroconversion models was restricted to 0.017.
bfor PfAMA1 and the combined antibody response the rate of reversion in the seroconversion models was restricted to 0.026.