Table 1.
CTL clonea | Restriction | SV 40 T ag epitope specificity | TCRβb | Fine specificityc |
---|---|---|---|---|
Y-1 | H-2Db | I | 7 | S206T |
A207G | ||||
N209T | ||||
K-11 | H-2Db | I | 10 | A212G/C |
Q213H | ||||
K-19 | H-2Db | II/III | 10 | NAd |
Y-5 | H-2Db | V | 7 | |
Q489A | ||||
D495A | ||||
H-1 | H-2Db | V | 9 |
References for the derivation and characterization of each of the CTL clones are provided in the text.
For additional information, see Mylin, et al. 2000.
Substituted epitope sequences which are differentially recognized by these pairs of CTL clones. For further information regarding the fine specificities of the epitope I-specific CTL clones Y-1 and K-11, see Lippolis, et al. 1995 and Tevethia, et al. 1998. The epitope V-specific CTL clones Y-5 and H-1 displayed differential recognition of alanine substituted synthetic peptides (Mylin and Tevehia, unpublished).
Not applicable.