Table III. Risk of breast cancer^* by 25-hydroxyvitamin D 24-hydroxylase (CYP24A1) and vitamin D receptor (VDR) genotype in U.S. Radiologic Technologists cohort.

Va riants	Cases/Controls	Odds ratio	95% CI		P_trend^**
*CYP24A1*
rs2248137
GG	174/325	1.00	-	-
CG	224/374	1.12	0.87	1.44
CC	77/144	1.00	0.71	1.40
CG+CC		1.08	0.86	1.38
Per allele		1.02	0.87	1.20	0.79

rs34043203
CC	345/631	1.00	-	-
TC	118/191	1.14	0.87	1.48
TT	18/13	2.81	1.35	5.87
TC+TT		1.25	0.97	1.61
Per allele		1.27	1.02	1.59	0.02

rs2296237
CC	296/508	1.00	-	-
TC	155/290	0.92	0.72	1.18
TT	23/43	0.93	0.55	1.59
TC+TT		0.92	0.73	1.17
Per allele		0.94	0.78	1.14	0.54

rs1977297
GG	372/691	1.00	-	-
GA	73/143	1.22	0.91	1.63
AA	7/7	2.10	0.72	6.09
GA+AA		1.27	0.96	1.69
Per allele		1.25	0.97	1.64	0.08

rs1570669
TT	209/327	1.00	-	-
TC	214/399	0.83	0.65	1.05
CC	53/114	0.73	0.50	1.05
TC+CC		0.82	0.65	1.03
Per allele		0.84	0.71	1.00	0.048

rs2762934
CC	298/566	1.00	-	-
TC	160/219	1.36	1.06	1.75
TT	17/18	1.79	0.90	3.54
TC+TT		1.39	1.09	1.78
Per allele		1.35	1.09	1.67	0.005

*VDR*
*rs1544410 (Bsm1)*
GG	185/290	1.00	-	-
GA	214/404	0.81	0.63	1.04
AA	67/144	0.69	0.49	0.97
GA+AA		0.78	0.61	0.98
Per allele		0.82	0.70	0.97	0.02

*rs2228570 (Fok1)*
CC	201/323	1.00	-	-
CT	206/385	0.85	0.67	1.09
TT	70/134	0.83	0.59	1.17
CT+TT		0.85	0.67	1.07
Per allele		0.90	0.76	1.06	0.20

Odds ratio (OR) were estimated using unconditional logistic regression with models adjusted for the frequency matching variable year of birth.

^**

P_trend reflects the significance level associated with the number of rare alleles (0, 1, or 2) in a log additive model.

Table III. Risk of breast cancer* by 25-hydroxyvitamin D 24-hydroxylase (CYP24A1) and vitamin D receptor (VDR) genotype in U.S. Radiologic Technologists cohort.