Table V.
Modification of associations between weekly hours spent outdoors in summer during the teen years (13-19 years) and breast cancer risk by vitamin D-related genotypes in the U.S. Radiologic Technologists cohort.
| Homozygous for the common allele | One or more rare alleles | |||||||
|---|---|---|---|---|---|---|---|---|
| Time outdoors (hours per week) | Cases/Controls | Estimates of association | Cases/Controls | Estimates of association | P for interaction | |||
| Polymorphism | Odds ratio (95% confidence interval) | P trend | Odds Ratio (95% confidence interval) | Ptrend | ||||
| VDR Fok1 (rs2228570) | CC | CT+TT | 0.01 | |||||
| ≤10.5 | 45/85 | 1.00 (ref) | 0.09 | 74/123 | 1.00 (ref) | 0.05 | ||
| 10.6-18.4 | 19/55 | 0.62 (0.33-1.18) | 40/69 | 0.92 (0.57-1.51) | ||||
| 18.5-28.5 | 58/75 | 1.43 (0.87-2.36) | 63/135 | 0.79 (0.52-1.21) | ||||
| ≥28.6 | 29/41 | 1.36 (0.74 -2.47) | 28/79 | 0.60 (0.36 -1.01) | ||||
|
| ||||||||
| VDR Bsm1 (rs1544410) | GG | GA+AA | 0.02 | |||||
| ≤10.5 | 38/85 | 1.00 (ref) | 0.18 | 79/120 | 1.00 (ref) | 0.06 | ||
| 10.6-18.4 | 20/37 | 1.11 (0.56-2.17) | 38/86 | 0.61 (0.38-1.00) | ||||
| 18.5-28.5 | 54/60 | 1.95 (1.14-3.33) | 67/150 | 0.68 (0.45-1.03) | ||||
| ≥28.6 | 23/43 | 1.12 (0.59-2.13) | 30/76 | 0.64 (0.38-1.07) | ||||
|
| ||||||||
| CYP24A1 (rs1570669) | TT | TC+CC | 0.003 | |||||
| ≤10.5 | 49/93 | 1.00 (ref) | 0.08 | 72/115 | 1.00 (ref) | 0.02 | ||
| 10.6-18.4 | 22/48 | 0.79 (0.43-1.47) | 36/75 | 0.72 (0.44-1.19) | ||||
| 18.5-28.5 | 53/79 | 1.30 (0.79-2.13) | 68/130 | 0.83 (0.55-1.27) | ||||
| ≥28.6 | 32/39 | 1.59 (0.88-2.87) | 24/81 | 0.47 (0.28-0.83) | ||||