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. 2014 Jan;20(1):76–87. doi: 10.1261/rna.041814.113

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© 2013 Ramalingam et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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FIGURE 4. — Schematic representation of identified ESTs in relation to host genes encoding intronic miRNA. (A) Schematic representation of human EST BX380440 in relation to the host gene EGFL7. The upper panel represents the exon–intron structure of the host gene EGFL7 (Ensembl transcript ID ENST00000308874) which codes for a 273-aa protein. miR 126 is hosted within intron 7 of EGFL7. The lower panel represents the gene structure of EST BX380440. Note that the EST shares the TSS and first seven exons with EGFL7. However, the precursor sequence of miR 126, which is part of intron 7 of the host gene EGFL7, becomes part of the unique exon 8 of BX380440 as a result of alternative splicing. EST BX380440 is a noncoding RNA and probably represents the pri-miRNA of miR 126. (B) Schematic representation of mouse ESTs in relation to the host gene AP-O. The upper panel represents the exon–intron structure of the host gene AP-O (Ensembl transcript ID ENSMUST00000021911). The arrows represent the location of TSS of the ESTs with respect to the host gene AP-O. The lower panels represent the gene structures of mouse ESTs BF301119 and AI286629 corresponding to miRs 27b and 24-1, respectively.