Figure 2.

Proposed model of immune regulation by SOCS1 mimetic peptides and antagonists. (Top) Cell penetrating SOCS1 antagonist peptides (pink loop) are internalized by various immune cells: macrophages (Mac), dendritic cells (DCs), regulatory T cells (Treg), and conventional T cell (T conv) where they antagonize the immuno-suppressive effects of native SOCS1. Inflammatory processes are enhanced, thus facilitating the elimination of cancers and viral infections. (Bottom) Cell penetrating SOCS1-KIR, which mimics the function of native SOCS1 (blue loop), is internalized by various immune cells (as above) where it enhances the immuno-suppressive effects of native SOCS1. Inflammatory processes are inhibited by cell penetrating SOCS1-KIR, thus inhibiting diseases which require dysregulated inflammation.