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The substrate binding site of 17β-HSD1. The nucleotide binding GxxxGxG motif and the residues involved in catalysis are shown in green. The NADPH is in purple and the estradiol in pink. Secondary structure elements are shown in grey. Some of the possible hydrogen bonds are shown by the black dashed lines. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
