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The sequence of human COMT. UniProt ID code P21964. The fifty residues present in mb-COMT but absent in s-COMT are shown in italics. The residue numbering, 1-271, is for mb-COMT: s-COMT is numbered 1–221 (shown in brackets) starting from residue 51 of mb-COMT. Highlighted is residue 158 (mb-COMT) or 108 (s-COMT) that is the site of a V/M polymorphism. Secondary structure elements are labelled: H – helix; S – sheet.
