Table 3.

The crystal structures of cytochrome P450 3A4. The structures of the ligands are shown in Fig. 22.

PDB code	Ligands	Reference
1TQN	–	[115]
1W0E	–	[116]
1W0F	Progesteronea	[116]
1W0G	Metyrapone	[116]
2J0D	Erythromycin A	[117]
2V0M	Ketoconazoleb	[117]
3NXU	Ritonavir	[118]
3TJS	Desthiazolylmethyloxycarbonyl ritonavir	[119]
3UA1	Bromoergocryptine	[120]

^aThe progesterone is not in the substrate binding site, but in a groove on the surface of the protein.

^bThere are two molecules of ketoconazole in the substrate binding site.