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Synthesis of 11 and its radiolabeling precursor, 15.a
aReagents and conditions: (a) 4-fluorobenzoylchloride (for 9) or 4-bromobenzoyl chloride (for 10), Et3N, toluene, 100 °C, 4 h–overnight; (b) MeNH2, K2CO3, 1,4-dioxane, 80 °C, 1.5 h (for 11) or 85 °C, 5 h (for 12); (c) DMAP, (Boc)2O, THF, 70 °C, 1 h; (d) (Bu3Sn)2, Pd(PPh3)4, 1,4-dioxane, overnight; (e) Koser’s reagent, 4 d.
