. Author manuscript; available in PMC: 2014 Nov 27.

Published in final edited form as: J Med Chem. 2013 Nov 7;56(22):10.1021/jm4012017. doi: 10.1021/jm4012017

Table 1.

Incorporation yields for reactions of [¹⁸F]fluoride ion with 15 under various conditions.^a

Entry	Conditions			Solvent	TEMPO (eq.)	[¹⁸F]F⁻ incorporation (%)
Entry	Energy source	Temp. (°C)	Time (min)	Solvent	TEMPO (eq.)	Putative [¹⁸F]16	[¹⁸F]11
1	Thermal	100	5	DMF	--	26	0
2	Thermal	100	5	DMF	2	39	3
3	μ-wave 100 W	60–140	2	DMF	2	40	11
4	μ-wave 90 W	61–113	2.5	MeCN	4	30	0
5	μ-wave 90 W	60–149	2	DMSO	2	9	40
6	μ-wave 90 W	60–152	4	DMSO	2	3	29
7	μ-wave 90 W	60–149	2	DMSO	2	n.m.	18 (n = 2)^b
8	μ-wave 90 W	60–152	2.5	DMSO	2	0–14	38 (n =13)^b

Amounts of precursor were 1.4–1.9 mg, and reaction volume was 500 μL.

Products from reactions 7 and 8 were analyzed on a semi-preparative HPLC column, whereas other reactions were analyzed on an analytical column.

n.m. = not measured