Table 3.
AcbSh | |||
---|---|---|---|
Line-pair | Canonical Pathway | Higher gene expression | Lower gene expression |
HAD2- LAD2 |
ILK Signaling | 9 genes: Map2k6, Pik3ca, Pik3c2a, Pik3r1, Vim, Myl9, Vegfb, Ppp1r12a, Rps6ka5 |
6 genes: Mapk8, Rhog, Rnd3, Pik3c3, Rsu1, Acta1 |
P-NP | cAMP-mediated signaling |
19 genes: Camk2d, Htr7, Atf4, Cnr1, Rapgef3, Pde8a, Pkib, Rps6ka1, Camk2g, Akap12, Pde4a, Chrm3, Ppp3cb, Adcy8, Adcy2, Adcy6, Crhr1, Gabbr2, Pth1r |
36 genes: Mapk1, Grm3, Camk2a, Adcy5, Ppp3r1, Rgs14, Pde2a, Grm8, Pde10a, Rgs4, Grm4, Drd2, Mc4r, Grm7, Pde1b, Pkig, Grm2, Camk4, Htr4, Chrm4, Htr1d, Pde1a, Hrh3, Akap11, Vipr1, Map2k1, Ppp3ca, Akap5, Npy1r, Prkar2b, Oprk1, Adra2c, Htr1f, Pde8b, Adora2a, Akap1 |
P-NP | G-Protein Coupled Receptor Signaling |
40 genes: Gpr37, Htr7, Atf4, Cnr1, Sstr1, Npy5r, Pde8a, Hcrtr1, Rps6ka1, Camk2g, Fzd1, Gprc5b, Pik3c3, Adcy6, Crhr1, Gpr64, Pth1r, Ntsr1, Gpr162, Casr, Gpr116, Camk2d, Adra1b, Grm1, Rapgef3, Hcrtr2, Cxcr7, Nfkbie, Pde4a, Nfkb1, Chrm3, Tacr1, Nfkbia, Smo, Adcy8, Adcy2, Trhr, Ednrb, Gabbr2, Plcb4 |
52 genes: Grm3, Gpr149, Camk2a, Pde2a, Grm8, Lphn3, Grm7, Pde1b, Fyn, Gpr12, Htr4, Ptk2b, Chrm4, Htr1d, Hrh3, Vipr1, Gpr155, Pik3r2, Bai2, Htr2a, Prkcg, Grm5, Rasgrp1, Adora2a, Prkcb, Mapk1, Pthlh, Pdpk1, Adcy5, Mras, Rgs14, Bai3, Pde10a, Rgs4, Grm4, Drd2, Mc4r, P2ry1, Grm2, Camk4, Pde1a, Map2k1, Npy1r, Gpr88, Gipr, Prkar2b, Sstr2, Oprk1, Calcr, Adra2c, Htr1f, Pde8b |
P-NP | Synaptic Long Term Potentiation |
12 genes: Gria4, Camk2d, Ppp3cb, Atf4, Adcy8, Ppp1r14c, Grm1, Ppp1r14a, Rapgef3, Plcb4, Rps6ka1, Camk2g |
24 genes: Grm2, Camk4, Mapk1, Grm3, Gria1, Camk2b, Camk2a, Ppp1r7, Ppp3r1, Mras, Map2k1, Ppp3ca, Grm8, Gria2, Itpr1, Grm4, Prkcg, Grm7, Grm5, Prkar2b, Ppp1r12a, Prkch, Gria3, Prkcb |
P-NP | Glutamate Receptor Signaling |
6 genes: Slc17a6, Grm1, Grip1, Gria4, Gng2, Grik1 |
16 genes: Grm2, Camk4, Grm3, Grm8, Gls, Gria1, Gria2, Slc1a3, Grm4, Gng7, Grm5, Grm7, Dlg4, Grik2, Homer1, Gria3 |
P-NP | Protein Kinase A Signaling |
28 genes: Dusp15, Camk2d, Atf4, Cdc16, Cdc25a, Ppp1r14c, Ptprd, Ppp1r14a, Gng3, Pde8a, Pygm, Dusp19, Gng2, Camk2g, Anapc2, Akap12, Nfkbie, Pde4a, Nfkb1, Nfkbia, Ppp3cb, Smo, Tgfb2, Adcy8, Adcy2, Adcy6, Pygb, Plcb4 |
37 genes: Mapk1, Ptpla, Ptk2, Gnb4, Camk2b, Camk2a, Ppp1r7, Adcy5, Ppp3r1, Ryr3, Ptpre, Pde2a, Pde10a, Ppp1r1b, Ptpn18, Itpr1, Pde1b, Tgfb3, Ppp1r12a, Prkch, Camk4, Ptk2b, Pde1a, Ptpn5, Gng7, Akap11, Dusp14, Map2k1, Ppp3ca, Akap5, Pygl, Prkcg, Prkar2b, Pde8b, Ptgs2, Prkcb, Akap1 |
P-NP | CREB Signaling in Neurons |
14 genes: Gria4, Camk2d, Pik3c3, Atf4, Adcy8, Grik1, Adcy2, Grm1, Adcy6, Gng3, Plcb4, Gng2, Rps6ka1, Camk2g |
26 genes: Grm2, Camk4, Mapk1, Grm3, Gria1, Gng7, Gnb4, Camk2b, Camk2a, Adcy5, Mras, Grik2, Pik3r2, Map2k1, Grm8, Gria2, Grm4, Itpr1, Prkcg, Grm5, Grm7, Prkar2b, Prkch, Gnal, Gria3, Prkcb |
P-NP | Calcium Signaling | 14 genes: Tnnc1, Atp2a2, Gria4, Camk2d, Ppp3cb, Atf4, Grik1, Hdac4, Myh14, Tpm2, Trpc4, Atp2b2, Tpm4, Camk2g |
21 genes: Tnnt1, Camk4, Mapk1, Atp2b1, Gria1, Tpm1, Camk2b, Camk2a, Ppp3r1, Ryr3, Ppp3ca, Casq2, Akap5, Tnnc2, Gria2, Itpr1, Prkar2b, Htr3a, Mef2c, Camkk2, Gria3 |
P-NP | Relaxin Signaling | 12 genes: Nfkbie, Pde4a, Nfkb1, Nfkbia, Pik3c3, Adcy8, Adcy2, Adcy6, Gng3, Pde8a, Gng2, Npr2 |
16 genes: Mapk1, Pde1a, Gng7, Gnb4, Adcy5, Mras, Pik3r2, Map2k1, Gucy1b3, Pde2a, Gucy1a3, Pde10a, Prkar2b, Pde1b, Pde8b, Gnal |
P-NP | Phospholipase C Signaling |
20 genes: Nfkb1, Rhog, Ppp3cb, Gpld1, Atf4, Adcy8, Adcy2, Hdac4, Pld3, Adcy6, Ppp1r14a, Arhgef17, Rapgef3, Gng3, Rhov, Plcb4, Rhoq, Rnd3, Gng2, Fnbp1 |
20 genes: Fyn, Camk4, Mapk1, Rps6ka3, Gng7, Gnb4, Adcy5, Ppp3r1, Mras, Arhgef2, Map2k1, Ppp3ca, Itpr1, Prkcg, Ppp1r12b, Ppp1r12a, Mef2c, Prkch, Arhgef9, Prkcb |
P-NP | Signaling by Rho Family GTPases |
21 genes: Pip5k1b, Sept9, Nfkb1, Limk1, Stmn1, Rhog, Pik3c3, Gfap, Cdc42ep1, Mapk8, Rdx, Arhgef17, Gng3, Mapk12, Rhov, Rhoq, Rnd3, Gng2, Pip4k2a, Sept6, Fnbp1 |
20 genes: Mapk1, Ptk2b, Gng7, Ptk2, Gnb4, Ezr, Baiap2, Mras, Arhgef2, Arpc1a, Pik3r2, Map2k1, Cdc42ep3, Wasf1, Pip5k1a, Ppp1r12b, Ppp1r12a, Pard3, Arhgef9, Gnal |
P-NP | Axonal Guidance Signaling |
28 genes: Bmp4, Ephb2, Adam11, Limk1, Tubb3, Sema5a, Gng3, Sema6d, Gng2, Rgs3, Slit1, Pdgfa, Fzd1, Tubb2b, Ppp3cb, Igf1, Tuba8, Pik3c3, Ntrk1, Smo, Rassf5, Plcb4, Ntrk2, Sema4d, Mag, Epha5, Sema3c, Gli1 |
34 genes: Slit3, Mapk1, Itsn1, Ptk2, Gnb4, Ephb1, Ppp3r1, Baiap2, Mras, Arpc1a, Ablim2, Epha7, Ngef, Kalrn, Vegfc, Prkch, Gnal, Fyn, Bmp2, Epha4, Plxna2, Gng7, Wnt7a, Pik3r2, Robo2, Shank2, Map2k1, Ppp3ca, Plxnc1, Slit2, Plxnd1, Prkcg, Prkar2b, Prkcb |
P-NP | Synaptic Long Term Depression |
8 genes: Gria4, Lcat, Igf1, Ppm1l, Grm1, Crhr1, Plcb4, Npr2 |
20 genes: Grm2, Mapk1, Grm3, Gria1, Ryr3, Mras, Map2k1, Gucy1b3, Gucy1a3, Grm8, Gria2, Itpr1, Grm4, Prkcg, Grm5, Grm7, Prkch, Gnal, Prkcb, Gria3 |
P-NP | α-Adrenergic Signaling |
7 genes: Adcy2, Adcy6, Pygb, Gng3, Pygm, Gng2, Adcy8 |
13 genes: Camk4, Mapk1, Pygl, Itpr1, Gng7, Prkcg, Gnb4, Prkar2b, Adcy5, Mras, Prkch, Map2k1, Prkcb |
P-NP | Gap Junction Signaling |
10 genes: Tubb2b, Ppp3cb, Tuba8, Pik3c3, Adcy8, Adcy2, Tubb3, Adcy6, Plcb4, Npr2 |
17 genes: Csnk1g1, Mapk1, Adcy5, Ppp3r1, Mras, Pik3r2, Map2k1, Ppp3ca, Gucy1b3, Htr2a, Gucy1a3, Itpr1, Drd2, Prkcg, Prkar2b, Prkch, Prkcb |
P-NP |
Dopamine Receptor Signaling |
10 genes: Ppp1r14c, Adcy2, Adcy6, Ppp1r14a, Slc18a3, Ppm1l, Smox, Adcy8, Pcbd1, Qdpr |
6 genes: Ppp1r1b, Drd2, Prkar2b, Ppp1r7, Adcy5, Ppp1r12a |
P-NP | Corticotropin Releasing Hormone Signaling |
10 genes: Smo, Atf4, Adcy8, Adcy2, Cnr1, Adcy6, Crhr1, Mapk12, Gli1, Npr2 |
13 genes: Camk4, Mapk1, Adcy5, Map2k1, Gucy1b3, Gucy1a3, Itpr1, Prkcg, Prkar2b, Mef2c, Prkch, Ptgs2, Prkcb |
P-NP | Dopamine- DARPP32 Feedback in cAMP Signaling |
13 genes: Kcnj16, Atp2a2, Ppp3cb, Ppm1l, Atf4, Adcy8, Ppp1r14c, Adcy2, Adcy6, Ppp1r14a, Plcb4, Kcnj5, Kcnj6 |
19 genes: Camk4, Csnk1g1, Kcnj4, Adcy5, Ppp1r7, Ppp3r1, Ppp3ca, Gucy1b3, Cacna1d, Gucy1a3, Ppp1r1b, Itpr1, Drd2, Prkcg, Prkar2b, Ppp1r12a, Prkch, Camkk2, Prkcb |
P-NP | CXCR4 Signaling* | 14 genes: Rhog, Pik3c3, Adcy8, Adcy2, Mapk8, Adcy6, Gng3, Mapk12, Plcb4, Rhov, Rhoq, Rnd3, Gng2, Fnbp1 |
14 genes: Mapk1, Gng7, Ptk2, Gnb4, Adcy5, Mras, Pik3r2, Map2k1, Egr1, Itpr1, Prkcg, Prkch, Gnal, Prkcb |
P-NP | ILK Signaling | 18 genes: Nfkb1, Ccnd1, Tgfb1i1, Rhog, Pik3c3, Ppm1l, Atf4, Itgb5, Myh14, Fermt2, Mapk8, Mapk12, Rhov, Rhoq, Rnd3, Sh2b2, Rsu1, Fnbp1 |
14 genes: Map2k6, Mapk1, Bmp2, Pdpk1, Ptk2, Myc, Pik3r2, Actn1, Casp3, Actn2, Vegfc, Ppp1r12a, Rps6ka5, Ptgs2 |
P-NP | Renin-Angiotensin Signaling* |
10 genes: Adcy2, Adcy6, Mapk8, Nfkb1, Mapk12, Pik3c3, Stat1, Adcy8, Ace, Agt |
13 genes: Ptk2b, Mapk1, Itpr1, Jak2, Prkcg, Ptk2, Prkar2b, Adcy5, Mras, Prkch, Pik3r2, Map2k1, Prkcb |
P-NP | IL-1 Signaling | 10 genes: Adcy2, Nfkbie, Mapk8, Adcy6, Gng3, Mapk12, Nfkb1, Nfkbia, Gng2, Adcy8 |
9 genes: Map2k6, Mapk1, Gng7, Gnb4, Prkar2b, Adcy5, Mras, Gnal, Irak2 |
CeA | |||
Line-pair | Canonical Pathway | Higher gene expression | Lower gene expression |
HAD1- LAD1 |
IL-8 Signaling | 6 genes: Ccnd2, Mapk1, Mapk8, Nfkb1, Ccnd1, Tek |
4 genes: Itgb2, Pik3ca, Pik3c2a, Mmp2 |
HAD2- LAD2 |
IGF-1 Signaling | 7 genes: Csnk2a2, Igfbp6, Pik3ca, Jun, Pik3c2a, Stat3, Igfbp2 |
3 genes: Pik3c3, Mapk8, Igfbp5 |
HAD2- LAD2 |
Cardiac Hypertrophy Signaling |
8 genes: Adcy9, Pik3ca, Pik3c2a, Gng13, Myl9, Jun, Eif2b1, Hspb1 |
6 genes: Mapk8, Eif4e, Rock2, Pik3c3, Eif2b5, Mef2c |
HAD2- LAD2 |
Breast Cancer Regulation by Stathmin1 |
Adcy9, Pik3ca, Pik3c2a, Gng13, Rb1cc1, Arhgef18, Prkd3 |
Rock2, Camk2a, Camk2d, Pik3c3, Arhgef9 |
HAD2- LAD2 |
IL-8 Signaling | 8 genes: Pik3ca, Pik3c2a, Gng13, Myl9, Jun, Vegfb, Prkd3, Itgb5 |
6 genes: Mapk8, Irak3, Rock2, Traf6, Pik3c3, Tek |
HAD2- LAD2 |
Role of NFAT in Cardiac Hypertrophy |
6 genes: Adcy9, Akap5, Pik3ca, Pik3c2a, Gng13, Prkd3 |
5 genes: Mapk8, Camk2d, Camk2a, Pik3c3, Mef2c |
There were no significant canonical pathways in the AcbSh or CeA for the AA-ANA and sP-sNP line-pairs. For the AcbSh, only pathways with 15 or more genes are listed. For the CeA, only pathways with 10 or more genes are listed.
Indicates that similar pathways were found in the AcbSh of the HAD2-LAD2 line-pair, but are not listed because there were less than 15 genes in each pathway. There were no genes in common within these pathways between the P-NP and HAD2-LAD2 line-pairs.