Table 4.
Networks identified by Ingenuity Pathway Analysis of significant differences in higher or lower gene expression in the AcbSh and CeA of the HEC compared to the LEC lines
| AcbSh | ||
|---|---|---|
| Network/main theme | Gene expression highera | Gene expression lowerb |
|
Network 1: Development and Function |
19 genes: Acss1, Cpne8, Ext2, Grk6, Grm8, Hsd17b7, Kif1a, Lcat, Maoa, Myh11, Nav2, Nfix, Phf20, Pias2, Sncg, Sp1, Suds3, Tagln, Tnrc6a |
11 genes: Arid4b, Gas7, Hk2, Igfbp4, Ing2, Lpxn, Nap1l1, Nr2f6, Rps19, Sf3a1, Wdr5 |
|
Network 2: Cellular Growth and Proliferation |
11 genes: Adcy9, Capn1, Cpt1a, Creg1, Dctn6, Gfap, Pou6f1, S100a6, Scg2, Stat3, Tgfa |
19 genes: Akt1s1, Axl, Blvrb, Bzw2, Epn2, Fkbp1a, Kitlg, Laptm5, Mlxipl, Myo5a, Npy, Ppp3ca, Ppp3r1, Pygl, Rock2, S100b, Sst, Txnl1, Wars |
|
Network 3: Nervous System Development and Function |
12 genes: Bcan, Dnm1, Grb14, Gria4, Grin3a, Hexim1, Mpp6, Numb, Reln, Rhot2, Rnf41, Zeb2 |
20 genes: Arf4, Camk2a, Cbr1, Efnb3, Egfr, Ephb1, Fyn, Gabbr1, Gda, Grin2b, Grm5, Kars, Lin7a, Map2, Mpp5, Pip5k1a, Scarf2, Sdc2, Shc2, Trak2 |
|
Network 4: Cell-To-Cell Signaling and Interaction |
14 genes: Ankrd12, B4galt1, Bag3, Caprin1, Cdk9, Cxcl12, Dlat, Dnajb1, Dync1h1, Hs2st1, Ppm1b, Sdf4, Tubgcp3, Yme1l1 |
17 genes: Arpc4, Copg, Copz1, Dad1, Dap3, Exosc2, Exosc5, Gapdhs, Lancl1, Mapk3, Mzf1, Pdk1, Phb2, Ptprz1, Ralgds, Sod3, Tmed9 |
|
Network 5: Cellular Assembly and Organization |
14 genes: Dhx36, Hif1a, Lrrc59, Map4, Pank2, Pfkp, Pgk1, Pik3r4, Plod2, Rb1cc1, Sephs1, Sh3glb1, Vps33a, Wdfy3 |
17 genes: Acp6, Aldh2, Atg10, Atg12, Atg4b, Camkk2, Ccs, Echs1, Erh, Fyco1, Gsto1, Mdh1, Prkaa2, Rgs10, Tars, Uba5, Wdr41 |
| CeA | ||
| Network/main theme | Gene expression highera | Gene expression lowerb |
|
Network 1: DNA Repair, RNA Damage and Repair |
18 genes: Abce1, Aifm2, Ccnl2, Col14a1, Comt, Creg1, Cul5, Gstm4, Hint1, Iqcb1, Morc3, Ncapd3, Ncaph, Ppm1a, Rnasel, Scn3b, Setd2, Vps33a |
17 genes: Cstf1, Fech, Mbnl2, Mcam, Nthl1, Phkg1, Polg, Ppp2r2a, Ppp2r5a, Rab40c, Rnf40, Sh3bgrl2, Slc6a6, Spsb1, Tbxas1, Tp53, Trio |
|
Network 2: Developmental Disorder, Neurological Disease |
18 genes: Adam9, Bbs1, Cep290, Eps8, Ercc8, Grb14, H1f0, Hdgfrp3, Hook3, Ipo5, MAST1, Pcm1, Pldn, Rnf41, Tmco3, Tmod2, Ttc8, Wdyhv1 |
16 genes: Ahnak, Apbb3, Axl, Cbr1, Ccng2, Egfr, Inppl1, Kif5c, Lin7a, Mdh1, Mpp3, Rab31, Shc1, Tmod1, Tpm1, Trak2 |
|
Network 3: Cellular Assembly and Organization, Cell-To-Cell Signaling and Interaction |
13 genes: Dcun1d4, Dhx36, Etv4, Flnb, Ipo4, Mlh1, Nedd9, Nup107, Phf20, Reln, Tgfb1i1, Trim23, Vav2 |
18 genes: Abcd3, C1qa, Fn1, Kdm5b, Map2, Nup93, Pde3b, Pex19, Phyh, Plec, Psd3, Ptp4a3, Rnaset2, Rragd, Swap70, Tmem14a, Tnfrsf11b, Tnfsf13 |
|
Network 4: Molecular Transport, RNA Trafficking |
13 genes: Bmpr1a, Bud13, Crmp1, Fam107b, Hif1a, Hnrnpul1, Ncbp1, Pias2, Plod2, Rad1, Tdg, Tgfb2, Thoc4 |
20 genes: Abcg1, Aldh2, Chd1l, Csf1r, Echs1, Fyco1, Hbegf, Hexb, Hk2, Il33, Nfia, Pias4, Ptafr, Purb, Rad51, Rpa1, S100a4, Sash3, Smad7, Uba5 |
|
Network 5: Cellular Function and Maintenance |
11 genes: Cul2, Eps15l1, Kif1a, Klf5, Lama1, Pcgf2, Rac1, Sap130, Sqstm1, Suds3, Usp7 |
16 genes: E2f6, Efna2, Elmo1, Enpp1, Epn2, Gas7, Kars, Laptm5, Limd1, Nqo1, Slc40a1, Snap23, Stx6, Timm44, Tomm70a, Usf2 |
a
Genes with higher expression in high vs. low ethanol consuming lines
b
Genes with lower expression in high vs. low ethanol consuming lines