Morphologic assessment of enteric ganglia in normal mice by Full-field optical coherence microscopy (FFOCM) and whole-mount immunohistochemistry (IHC). Representative images from FFOCM (imaged from the serosal side) and PGP9.5 (green)/Hu (red) whole-mount IHC were obtained from the proximal colon (A,D), mid colon (B,E), and rectum (C,F). The colorectum displays normal-appearing enteric ganglia consisting of groups of neuronal cell bodies connected by interganglionic nerve fibers. FFOCM images are representative ‘real’ single images. Confocal microcopy images are shown with larger field of view to provide representative images of a large gut segment. Scale bars in C and F are 100 μm.