Table 1.
SMA | - | increased expression of myogenin, MuRF1 and atrogin 1 in SMA model mice and SMA human muscle samples (Bricceno et al., 2012b) |
- | TSA administration reduced the levels of atrogenes in SMA model mice (Bricceno et al., 2012b) | |
ALS | - | increased levels of atrogin 1 but not MuRF1 in ALS SOD1G93A model mice and ALS human samples (Léger et al., 2006) |
- | decreased levels of AKT in ALS human samples (Léger et al., 2006) | |
- | increased levels of FoxO3 and MuRF1 but not atrogin1 in MLC/SOD1G93A animals (Dobrowolny et al., 2005) | |
- | increased levels of expression of autophagy genes in MLC/SOD1G93A mice (Dobrowolny et al., 2005) |