Table 1.

Summary of pathways leading to muscle atrophy in motor neuron diseases.

SMA	-	increased expression of myogenin, MuRF1 and atrogin 1 in SMA model mice and SMA human muscle samples (Bricceno et al., 2012b)
	-	TSA administration reduced the levels of atrogenes in SMA model mice (Bricceno et al., 2012b)
ALS	-	increased levels of atrogin 1 but not MuRF1 in ALS SOD1G93A model mice and ALS human samples (Léger et al., 2006)
	-	decreased levels of AKT in ALS human samples (Léger et al., 2006)
	-	increased levels of FoxO3 and MuRF1 but not atrogin1 in MLC/SOD1G93A animals (Dobrowolny et al., 2005)
	-	increased levels of expression of autophagy genes in MLC/SOD1G93A mice (Dobrowolny et al., 2005)