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. Author manuscript; available in PMC: 2014 Oct 10.
Published in final edited form as: J Med Chem. 2013 Sep 19;56(19):10.1021/jm401184f. doi: 10.1021/jm401184f

Figure 7.

Figure 7

Blockade of [18F]7a accumulation in CD-1 mouse brain regions by injection of cytisine (1 mg/kg, s.c.) and nicotine (5 mg/kg, s.c.) (both 90 min after the injection). Data: mean %injected dose/g tissue ± SD (n = 3). Abbreviations: Coll = superior and inferior colliculus; Hipp = hippocampus; Ctx = cortex; CB = cerebellum; Rest = rest of brain. The effect of cytisine was insignificant in all regions studied (P > 0.05, asterisk is not shown). The difference between control and nicotine was significant (*P ≤ 0.01) in all regions, except CB (**P = 0.9) (ANOVA). The study demonstrates that [18F]7a does not bind in vivo at the main cerebral α4β2-nAChR subtype and it is suitable for nicotine blockade studies.