. Author manuscript; available in PMC: 2014 Oct 10.

Published in final edited form as: J Med Chem. 2013 Sep 19;56(19):10.1021/jm401184f. doi: 10.1021/jm401184f

Table 1.

In vitro properties and binding potential in cortex (BP_ND) of the previously published PET/SPECT radioligands for imaging of α7-nAChR.

Radioligand	α7-nAChR, K_i, nM	BP_ND^a		References
Radioligand	α7-nAChR, K_i, nM	Mice	Monkey or pig	References
	0.26	0.6	-	¹⁸
	n/a	~ 0	-	²¹
	10.8	0.2 – 0.5	0.3	²²
	11	0.6 – 0.7	0.5	²²
	0.24, 1.53	0.5	-	²³
	46, 120, 193	~ 0.1	0.6	^{19, 25, 38, 39}
	40.6	0.4	0.4	²⁰
	0.092	low brain uptake	low brain uptake	²³
	0.5 – 0.6	1.9	-	²⁴
	2.5	low brain uptake	-	²⁸
	24.9	-	0.7	¹⁹
	2.2	-	~ 1	²⁶
	11.6	0.4	0.8	²⁹
	0.2	0.8	-	^{27, 40}

The BP_ND values in cortex were taken directly from the corresponding references or estimated as V_T/V_ND − 1 or (cortex uptake/cerebellum uptake) − 1.^{41, 42}