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. Author manuscript; available in PMC: 2014 Oct 10.
Published in final edited form as: J Med Chem. 2013 Sep 19;56(19):10.1021/jm401184f. doi: 10.1021/jm401184f

Table 1.

In vitro properties and binding potential in cortex (BPND) of the previously published PET/SPECT radioligands for imaging of α7-nAChR.

Radioligand α7-nAChR,
Ki, nM
BPNDa References
Mice Monkey or
pig
graphic file with name nihms526307t1.jpg 0.26 0.6 - 18
graphic file with name nihms526307t2.jpg n/a ~ 0 - 21
graphic file with name nihms526307t3.jpg 10.8 0.2 – 0.5 0.3 22
graphic file with name nihms526307t4.jpg 11 0.6 – 0.7 0.5 22
graphic file with name nihms526307t5.jpg 0.24, 1.53 0.5 - 23
graphic file with name nihms526307t6.jpg 46, 120, 193 ~ 0.1 0.6 19, 25, 38, 39
graphic file with name nihms526307t7.jpg 40.6 0.4 0.4 20
graphic file with name nihms526307t8.jpg 0.092 low brain uptake low brain uptake 23
graphic file with name nihms526307t9.jpg 0.5 – 0.6 1.9 - 24
graphic file with name nihms526307t10.jpg 2.5 low brain uptake - 28
graphic file with name nihms526307t11.jpg 24.9 - 0.7 19
graphic file with name nihms526307t12.jpg 2.2 - ~ 1 26
graphic file with name nihms526307t13.jpg 11.6 0.4 0.8 29
graphic file with name nihms526307t14.jpg 0.2 0.8 - 27, 40
a

The BPND values in cortex were taken directly from the corresponding references or estimated as VT/VND − 1 or (cortex uptake/cerebellum uptake) − 1.41, 42