Table 1.
The global profile of mesenchymal stem cell (MSC)-derived molecules associated with renoprotection.
| MSC-related molecules | Biologic Function | Source of MSC | References |
|---|---|---|---|
| IL-10, TGF-β | Anti-Inflammatory | Mouse and Rat | 55, 57, 58, 61 |
| EPO, FGF-2, IGF, PDGFR and SM22 α | Pro-Angiogenic | Mouse and Rat | 70, 72, 71, 74 |
| VEGF, -D, HGF, IGF, SDF-l and LIF | Stimulation of Endogenous Progenitor Cells | Mouse, Rat and Human | 57, 80, 81 |
| IGF, HGF and VEGFs | Anti-Apoptotic | Mice and Human | 80, 90 |
| HGF, MMPs and TIMPs | Anti-Fibrotic | Rat | 88 |
| EPO and HO-l | Anti-Oxidant | Mouse | 70, 95 |
| MVs, mRNAs and miRNAs | Promotion of Cellular Reprogramming | Mice and Human | 103, 104, 105, 106 |
EPO, Erythropoietin; FGF-2, Fibroblast growth factor 2; HGF, Hepatocyte growth factor; HO-1, Heme oxygenase-1; IGF, Insulin-like growth factor; IL-10, Interleukin 10; LIF, Leukemia inhibitory factor; MMPs, Matrix metalloproteinases; MV, microvesicle; PDGFR, Platelet-derived growth factor receptor; SDF-1, Stromal cell-derived factor-1; SM22α, 22-kDa smooth muscle cell marker; TGF-β, Transforming growth factor beta; TIMPs, Tissue inhibitors of metalloproteinase; VEGF, Vascular endothelial growth factor.