Figure 3.

Synuclein exhibits prion strain-like properties. Fibrils of recombinant synuclein were taken up by primary neurons and the derived fibrils used for repetitive seeding of additional primary cultures. Early passages yield fibrils capable of forming only inclusions of synuclein (strain A). Fibrils derived from subsequent passages produced robust tau pathology with less deposition of synuclein (strain B). Both strains may derive from the same initial fibrillization reaction (gray arrows), but it seems more likely that strain A converts into strain B. (Adapted from Guo et al., 2013)