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. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: Virology. 2013 May 29;443(1):10.1016/j.virol.2013.05.009. doi: 10.1016/j.virol.2013.05.009

Fig. 1. Mouse RNase L potently inhibits FV in vitro.

Fig. 1

Expression plasmids encoding murine Apobec3, RNaseL or empty vector were co-transfected with an F-MuLV molecular clone, pLRB302, into 293T cells. Serial 3-fold dilutions of the supernatants were used to infect Mus dunni cells, and after 48 h, cells were fixed and stained with a monoclonal antibody (MAb 720) against the FV envelope protein. Foci were counted and infectious titers were calculated per ml of supernatant. Mean fold-differences relative to vector control are shown. P values were calculated using 2-tailed Student’s t test, with p<0.05 considered statistically significant.