Figure 1.

Spectrum of antineoplastic agent potential to necessitate clinical intervention if extravasated. ^aExamples of DNA-binding agents include the anthracyclines. Examples of non-DNA-binding agents include the taxanes. ^bFor definitions of dilute and concentrated drug, refer to the manufacturer’s prescribing information for individual antineoplastic agents. ^cFor recommended administration sites, refer to current clinical practice guidelines [Neuss et al. 2013; Polovich et al. 2009]. ^dClinical intervention may include administration of antidote and/or surgery in addition to the standard application of ice for DNA-binding agents and a warm compress from non-DNA-binding agents.